Activation and regulation of Toll-Like Receptors (TLRs) by helminth parasites
Identifieur interne : 006414 ( Main/Exploration ); précédent : 006413; suivant : 006415Activation and regulation of Toll-Like Receptors (TLRs) by helminth parasites
Auteurs : Priyanka Goel Venugopal ; Thomas B. Nutman ; Roshanak Tolouei SemnaniSource :
- Immunologic Research [ 0257-277X ] ; 2009.
Descripteurs français
- KwdFr :
- MESH :
- agonistes : Récepteurs de type Toll.
- immunologie : Brugia malayi, Cytokines, Filariose lymphatique, Récepteurs de type Toll, Schistosoma, Schistosomiase, Wuchereria bancrofti.
- Animaux, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , agonists : Toll-Like Receptors.
- chemical , immunology : Cytokines, Toll-Like Receptors.
- immunology : Brugia malayi, Elephantiasis, Filarial, Schistosoma, Schistosomiasis, Wuchereria bancrofti.
- Animals, Humans.
Abstract
Helminth (worm) infections are major public health problems that have important socioeconomic consequences for the more than 2 billion infected individuals. Chronicity (their hallmark) can lead to anemia (in hookworm infection), river blindness (onchcerciasis), cirrhosis (schistosomiasis), and elephantiasis (lymphatic filariasis). Although there have been many studies examining innate immune responses (including TLR expression and function) in response to intracellular pathogens, fewer have examined the interaction of the multicellular helminth parasites and the innate immune system. This review will focus on two “systemic” helminth parasitic infections (lymphatic filariasis and schistosomiasis) and the regulation of TLRs that may contribute to infection outcome.
Url:
DOI: 10.1007/s12026-008-8079-0
PubMed: 18982454
PubMed Central: 3398210
Affiliations:
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Le document en format XML
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Nutman</name></author><author><name sortKey="Semnani, Roshanak Tolouei" sort="Semnani, Roshanak Tolouei" uniqKey="Semnani R" first="Roshanak Tolouei" last="Semnani">Roshanak Tolouei Semnani</name></author></analytic><series><title level="j">Immunologic Research</title><idno type="ISSN">0257-277X</idno><idno type="eISSN">1559-0755</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brugia malayi (immunology)</term><term>Cytokines (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Humans</term><term>Schistosoma (immunology)</term><term>Schistosomiasis (immunology)</term><term>Toll-Like Receptors (agonists)</term><term>Toll-Like Receptors (immunology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Brugia malayi (immunologie)</term><term>Cytokines (immunologie)</term><term>Filariose lymphatique (immunologie)</term><term>Humains</term><term>Récepteurs de type Toll (agonistes)</term><term>Récepteurs de type Toll (immunologie)</term><term>Schistosoma (immunologie)</term><term>Schistosomiase (immunologie)</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="agonists" xml:lang="en"><term>Toll-Like Receptors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cytokines</term><term>Toll-Like Receptors</term></keywords><keywords scheme="MESH" qualifier="agonistes" xml:lang="fr"><term>Récepteurs de type Toll</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia malayi</term><term>Cytokines</term><term>Filariose lymphatique</term><term>Récepteurs de type Toll</term><term>Schistosoma</term><term>Schistosomiase</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Schistosoma</term><term>Schistosomiasis</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Helminth (worm) infections are major public health problems that have important socioeconomic consequences for the more than 2 billion infected individuals. Chronicity (their hallmark) can lead to anemia (in hookworm infection), river blindness (onchcerciasis), cirrhosis (schistosomiasis), and elephantiasis (lymphatic filariasis). Although there have been many studies examining innate immune responses (including TLR expression and function) in response to intracellular pathogens, fewer have examined the interaction of the multicellular helminth parasites and the innate immune system. This review will focus on two “systemic” helminth parasitic infections (lymphatic filariasis and schistosomiasis) and the regulation of TLRs that may contribute to infection outcome.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name><name sortKey="Semnani, Roshanak Tolouei" sort="Semnani, Roshanak Tolouei" uniqKey="Semnani R" first="Roshanak Tolouei" last="Semnani">Roshanak Tolouei Semnani</name><name sortKey="Venugopal, Priyanka Goel" sort="Venugopal, Priyanka Goel" uniqKey="Venugopal P" first="Priyanka Goel" last="Venugopal">Priyanka Goel Venugopal</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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